IL-2: From T Cell Growth Factor to Immunoregulatory Hub - A Receptor Signaling Panorama
A core member of the class I cytokine family, IL-2 activates the JAK1/JAK3-STAT5 pathway through its ternary receptor complex. This article reviews receptor composition, signaling hierarchy, affinity stratification, and immunoregulatory research tool
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Abstract: A core member of the class I cytokine family, IL-2 activates the JAK1/JAK3-STAT5 pathway through its ternary receptor complex. This article reviews receptor composition, signaling hierarchy, affinity stratification, and immunoregulatory research tools including biotinylated reagents.
Keywords: IL-2, IL-2 receptor, JAK1, JAK3, STAT5, Treg, biotinylated
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
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