The CD3 Complex and T-Cell Activation: From ITAM Phosphorylation to TCE Design Foundations
Composed of εδ and εγ heterodimers plus ζζ, the CD3 complex is the transduction core of TCR signaling. This review covers its subunit composition, the ITAM phosphorylation hierarchy and the structural basis for T-cell engager design.
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Keywords: CD3,TCR complex,ITAM,ZAP-70,T-cell activation,CD3epsilon-gamma,UA016046
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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