The CD3 Arm of T-Cell Engagers: Why Development Starts with Heterodimeric Proteins
The same CD3 arm can be precision guidance or a cytokine storm. Along the design challenges of T-cell engagers, this article dissects why the CD3εγ heterodimer has become the standard starting tool for bispecific antibody development.
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Keywords: CD3,CD3epsilon-gamma heterodimer,T-cell engager,Affinity tuning,Cytokine release,UA016046
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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