Skin Fragility, Neuropathy and Tumor Metastasis: Three Lines of Defense Lost When Plectin Fails
Loss of Plectin function follows one main thread—cytoskeletal cross-link failure leading to tissue mechanical fragility—manifesting as EBS-MD, peripheral neuropathy and mechanically driven tumor metastasis in different tissues. This article dissects
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Keywords: Plectin,Epidermolysis bullosa simplex,Cytoskeletal disease,Mechanotransduction metastasis,NHP model,UA016101
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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