Plectin: Structural Basis and Research Landscape of the Cytoskeletal Cross-linking Network
Plectin bridges actin microfilaments, microtubules and intermediate filaments through its N-terminal ABD, central coiled-coil rod and C-terminal plakin repeat domains. This article systematically reviews its structural boundaries, regulation, disease
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Abstract: Plectin bridges actin microfilaments, microtubules and intermediate filaments through its N-terminal ABD, central coiled-coil rod and C-terminal plakin repeat domains. This article systematically reviews its structural boundaries, regulation, disease associations and experimental design considerations, providing a panoramic view for cytoskeleton and mechanobiology research.
Keywords: Plectin,Cytoskeletal cross-linker,ABD domain,Intermediate filament,Hemidesmosome,UA016101
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
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