UA BIOSCIENCE Company Introduction

Author: Senior Product Manager of UA Views：9

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UA BIOSCIENCE Company Introduction

1. Brand Overview

UA BIOSCIENCE (Nanjing UA Bioscience R&D Co., Ltd.), a subsidiary of Uninovo Group (Stock Code: 301166), is a domestic specialized supplier focused on recombinant protein R&D, production, and technical services. Established in 2018 with a registered capital of 60 million RMB, the company is located in the integrated R&D and production base of Nanjing Lishui Yongyang Industrial Park. It boasts over 1,000 square meters of standardized protein R&D, purification, and functional validation laboratories, equipped with full sets of ultracentrifuges, affinity chromatography, HPLC, and flow cytometry devices. With a multi-expression platform covering prokaryotic, yeast, insect, and mammalian cell systems, UA BIOSCIENCE provides one-stop domestic protein reagents and custom development services for basic research, antibody drugs, ADC, CAR-T, PROTAC, cell therapy, autoimmune and tumor immunology drug development through a standardized quality control system.

UA BIOSCIENCE adheres to the core philosophy of "Quality Drives Innovation, Service Empowers Research," specializing in the localization of upstream recombinant protein raw materials. It aims to create high-activity, high batch-to-batch consistency, and cost-effective domestic recombinant protein tools to break the dependence on imported high-end protein reagents. Its products have been cited in multiple high-impact journals such as JTO and JACS, serving universities, top-tier hospitals, innovative pharmaceutical companies, and CRO enterprises nationwide.

Address: No. 6 Runli Road, Yongyang Street, Lishui District, Nanjing, Jiangsu Province, China
Website: https://www.ua-bio.com/
Contact: 025-56221161; Technical Email: order@ua-bio.com

2. Core Product Portfolio (Key Advantages)

(1) Comprehensive Cytokine Product Line (Flagship Products)

Cytokines are UA BIOSCIENCE's core competitive advantage, covering all experimental scenarios with three tiers:

Standard Research-Grade Cytokines
Includes interleukins (IL-2/IL-7/IL-15/IL-21/IL-23, etc.), growth factors, interferons, chemokines, tumor necrosis factors, colony-stimulating factors, Activin A, GDF-8 myostatin, TSLP, IL-33, and other immune regulatory proteins. All products feature high purity, high activity, low endotoxin levels, and minimal batch-to-batch variation, suitable for T cell, NK cell, macrophage, stem cell, organoid culture differentiation, and inflammatory pathway research.

GMP-Grade Cytokines (Key Industrial Product Line)
Produced in strict compliance with GMP standards, with full batch traceability. Core products include IL-2, IL-7, IL-15, IL-21, and fibronectin. Custom animal-free options are available to meet CAR-T and immune cell expansion preclinical R&D and pilot-scale production needs, with activity comparable to imported brands at significantly lower costs.

Cell Culture Activation/Polarization Kits (Ready-to-Use Reagent Sets)
Complete with experimental protocols for immediate use, eliminating reagent preparation steps:

① T Cell Activation/Polarization Kit: Supports Th1/Th2/Th17/Treg/Tfh subtype induction;

② Macrophage Polarization Kit: M0/M1/M2 subtype induction, including a specialized kit for mouse RAW264.7 cells;

③ B Cell Polarization Kit;

④ Organoid-Specific Culture Kits for lung, stomach, small intestine, bile duct, and colon;

Includes flow cytometry validation protocols, enabling beginners to quickly complete immune cell polarization experiments.

(2) Full Range of Drug Target Recombinant Proteins (Covering Four Innovative Drug Fields)

Leveraging mammalian expression systems to accurately replicate human protein glycosylation and multimeric conformations, covering mainstream drug targets:

Immune Checkpoint Antibody Targets
PD-1, PD-L1, CTLA-4, LAG-3, TIGIT, TIM-3, 4-1BB, OX40, B7-H2; for neutralizing antibody screening, molecular binding activity, and immune blockade function evaluation.

ADC Drug-Specific Target Proteins
Detergent-formulated full-length Claudin 18.2, Nectin-4, Siglec-2, Siglec-3, FOLR1, B7-H4, CD38, ROR1, CD27 Ligand; preserves extracellular antigen epitopes for ADC antibody and bispecific antibody binding and affinity testing.

CAR-T Cell Therapy Targets
CD19, BCMA, CD22, CD30, CD33, CD4, CD20, CD23, CD138; for CAR molecule affinity validation and in vitro cell-killing function assessment.

Small Molecule/PROTAC Hot Targets
KRAS, EGFR, JAK1/2/3, ALK, PARP, USP family, STAT6, IRAK4; paired with CRBN, VHL E3 ubiquitin ligase complexes, and BRD4 proteins for PROTAC degrader screening and reporter gene assays.

Full-Length Multi-Transmembrane Protein Specialties
Rare domestic full-length GPCRs, transporters, and ion channel membrane proteins (CCR4, CD20, CLDN18.2, ABCD1, SLC7A11, etc.); proprietary detergent screening and nanodisc stabilization technologies maintain native transmembrane conformations for small-molecule drug screening, SPR interaction, and cell-binding assays; includes glycosylation structure characterization services (PNGase F, IdeS cleavage analysis).

Fc Receptor Series
Full range of FcγR and FcRn recombinant proteins with human-like glycosylation for antibody ADCC/ADCP evaluation, half-life modification, and IgG subtype binding profiling.

(3) ADC Antibody Internalization Efficiency Tools (Unique Differentiated Products)

Addressing core challenges in ADC drug early screening with a complete domestic toolset:

pH-sensitive fluorescent IgG labeling kit (ready-to-use);

DT3C recombinant diphtheria toxin domain protein;

High-sensitivity, easy-to-use tools for rapid assessment of antibody internalization and drug delivery efficiency, shortening ADC candidate screening cycles.

(4) Enzymes, Detection Kits & MHC Tetramers

Enzyme Series
Glycosylation-cleaving enzymes (PNGase F, IdeS), fusion tag removal enzymes, drug conjugation enzymes, peptide sequencing enzymes; for protein characterization, antibody modification, and sample preprocessing.

UA-Glo® Luciferase/Kinase Assay Kits
Dual-luciferase, live-cell nanoluciferase, and kinase ADP detection systems with stable signals and low background, suitable for signaling pathway screening and PROTAC reporter gene assays.

MHC Tetramers
Covering tumor neoantigens (KRAS G12D), HPV, EBV, influenza A, and universal model antigen tetramers; for antigen-specific T cell sorting and TCR-T target validation, validated by multiple high-impact publications.

(5) One-Stop Custom Recombinant Protein Services (Industrial-Grade Full Process)

Standardized four-step delivery: plasmid construction → recombinant protein expression → multi-step chromatography purification → comprehensive QC report;

Supports E. coli, Pichia pastoris, insect cells, and HEK293/CHO mammalian expression systems; specializes in full-length transmembrane protein customization, membrane protein nanodisc preparation, stable cell line development, and glycosylation analysis; handles orders from small-scale research to pilot-scale drug production.

3. Core Competitive Advantages

Native Protein Conformation: Primarily using mammalian expression systems to accurately replicate human protein glycosylation and multimeric modifications; transmembrane proteins employ specialized stabilization techniques, with activity significantly superior to prokaryotic-expressed counterparts.

Rigorous Quality Control: Each batch undergoes HPLC purity, WB identification, endotoxin testing, and cell functional activity validation, with batch-to-batch activity variation controlled within 5%.

Comprehensive R&D Solutions: From target proteins, cytokines, detection kits to custom services, covering the entire R&D chain for antibody drugs, ADC, CAR-T, PROTAC, cell therapy, and autoimmune diseases, eliminating multi-vendor procurement.

Cost-Effective Domestic Supply + Rapid Delivery: Core products are stocked for immediate shipment, offering far lower prices than imported brands at comparable quality; available in research-grade, GMP-grade, and animal-free options.

Full Technical Support: Website features experimental video tutorials, standardized protocols, and technical articles; provides hands-on guidance for T cell activation, macrophage polarization, membrane protein purification, and PROTAC degradation, with professional after-sales support.

4. Tailored Solutions for Specific Fields

Customized product combinations for different R&D areas:

Cancer Immunotherapy Antibody Development: Immune checkpoint target proteins + neutralization assay kits

ADC Drug Development Suite: Full-length membrane antigen targets + antibody internalization tools

CAR-T Cell Expansion Solution: GMP-grade cytokines + T cell activation/polarization kits

PROTAC Degrader Screening: E3 ubiquitin ligases + target proteins + fluorescent reporter kits

Autoimmune/Inflammation Research: IL-23/IL-17, TSLP/IL-33 cytokine sets

Stem Cell/Organoid Culture Cytokine Kits

5. Corporate Vision

Leveraging Uninovo Group's mature supply chain, distribution, and R&D resources, UA BIOSCIENCE continues to advance recombinant protein expression and purification platforms, focusing on domestic production of innovative drug core biologics. With stable, high-activity, and highly compatible domestic recombinant protein reagents, we empower research institutions and biopharmaceutical companies to accelerate drug development, aiming to become China's leading and globally competitive recombinant protein specialist.