HRSV Pre-fusion F: Why the F Protein Must Be Locked Before Fusion

The RSV F protein rearranges irreversibly from pre- to post-fusion conformations, and most neutralizing epitopes only exist in the pre-fusion state. This article explains the conformational locking logic.

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Abstract: The RSV F protein rearranges irreversibly from pre- to post-fusion conformations, and most neutralizing epitopes only exist in the pre-fusion state. This article explains the conformational locking logic.

Keywords: RSV, pre-fusion F protein, fusion glycoprotein, conformational locking, neutralizing epitope, site Ø, UA030095

Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.

This article is reviewed and published by the technical expert team of UA

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