IGF1R/CD221: Structure, alpha2beta2 Assembly and the Tumor Research Landscape of a Receptor Tyrosine Kinase
IGF1R/CD221 is a receptor tyrosine kinase of the insulin receptor family, assembled as an alpha2beta2 heterotetramer. This review covers its molecular architecture, IGF-1/IGF-2 ligand recognition, PI3K-AKT and RAS-RAF-MEK-ERK signaling, and key point
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Keywords: IGF1R, CD221, alpha2beta2, RTK, IGF-1, IGF-2, PI3K/AKT, RAS/RAF/MEK/ERK, UA016082
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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