ACVR2A (ActRIIA): Signaling Mechanisms and Ligand Network of a TGF-beta Superfamily Type II Receptor

ACVR2A (ActRIIA) is a type II serine/threonine kinase receptor of the TGF-beta superfamily. This review covers its molecular features, the activin/myostatin ligand network, SMAD2/3 signaling cascades, and key points in tumor and muscle research.

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Abstract: ACVR2A (ActRIIA) is a type II serine/threonine kinase receptor of the TGF-beta superfamily. This review covers its molecular features, the activin/myostatin ligand network, SMAD2/3 signaling cascades, and key points in tumor and muscle research.

Keywords: ACVR2A, ActRIIA, activin receptor 2A, TGF-beta superfamily, myostatin, SMAD2/3, UA085066

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This article is reviewed and published by the technical expert team of UA

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