MAT1A: Catalytic Mechanism and Research Landscape of Methionine Adenosyltransferase

MAT1A (EC 2.5.1.6) catalyzes methionine and ATP into SAM, the entry enzyme of one-carbon metabolism. This review covers its two-step catalytic mechanism, oligomeric states, division of labor with MAT2A, disease associations and in vitro research esse

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Abstract: MAT1A (EC 2.5.1.6) catalyzes methionine and ATP into SAM, the entry enzyme of one-carbon metabolism. This review covers its two-step catalytic mechanism, oligomeric states, division of labor with MAT2A, disease associations and in vitro research essentials.

Keywords: MAT1A, methionine adenosyltransferase, SAM, one-carbon metabolism, MAT I/III, isoenzymes, UA0800468

Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.

This article is reviewed and published by the technical expert team of UA

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