A Four-Leg Relay: How CD3εδ Translates Antigen Recognition into T Cell Activation
T cell activation is a relay race: TCR-alpha/beta binds the pMHC, CD3εδ and CD3εγ transmit the conformational change across the membrane, CD3ζζ converts it into ITAM phosphorylation, and ZAP-70 takes the final leg. This article walks through each bat
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Keywords: CD3, CD3εδ heterodimer, TCR, ITAM, ZAP-70, T cell activation
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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