The CRBN-DDB1 Complex: Substrate-Recognition Core of the CRL4 Ubiquitin Ligase
As the substrate receptor of the CRL4 E3 ubiquitin ligase, CRBN relies on DDB1 to bridge the Cullin4-RBX1 core for ubiquitin transfer. This article systematically dissects the complex assembly logic, molecular glue mechanisms and in vitro research es
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Keywords: CRBN-DDB1,Molecular glue,E3 ubiquitin ligase,CRL4,Substrate receptor,UA085062
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
This article is reviewed and published by the technical expert team of UA
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