A Force Transmission Chain: The Pivotal Role of Plectin in Mechanotransduction
Mechanical forces travel from the extracellular matrix through integrin–focal adhesion complexes and the Plectin-bridged cytoskeletal network, ultimately shaping YAP/TAZ transcriptional responses. This article breaks down each segment of the chain an
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Abstract: Mechanical forces travel from the extracellular matrix through integrin–focal adhesion complexes and the Plectin-bridged cytoskeletal network, ultimately shaping YAP/TAZ transcriptional responses. This article breaks down each segment of the chain and the methods to verify it.
Keywords: Plectin,Mechanotransduction,Focal adhesion,YAP TAZ,Matrix stiffness,UA016100
Note: The full article is published in Chinese. Please refer to the Chinese version for complete experimental details, figures and product references. For product inquiries, visit www.ua-bio.com.
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