Product Application

Apoptosis is a genetically regulated programmed cell death that plays a central role in development, immune homeostasis, tissue renewal, and tumorigenesis. The caspase family (cysteine-aspartic proteases) serves as key executioners of apoptosis: initiator caspases (e.g., Caspase-8/9) sense death signals and subsequently activate executioner Caspase-3/7 through a cascade. These effector caspases cleave substrates such as PARP and cytoskeletal proteins, ultimately leading to cellular disintegration.