Technical Articles
pathway crosstalk
Regulatory network of the IL-23/IL-17A signaling axis and the logic of dual-target development
2026-06-23IL-23 and IL-17A do not function in isolation but form a complete signaling axis from innate immunity to adaptive immunity, and from antigen presentation to tissue inflammation. The core components of this axis include: IL-23 activates the STAT3-RORγt transcriptional program via IL-23R, driving Th17 cell differentiation; Th17 cells secrete IL-17A and IL-17F; IL-17A activates the NF-κB and MAPK pathways in target tissues through IL-17RA/IL-17RC, inducing the expression of inflammatory genes.
View details
- Immunity/Inflamma
- IL-23/IL-17 axis
- Th17 regulatory network
- pathway crosstalk
- bispecific antibodies
- oral cyclic peptides
Regulatory network of the IL-23/IL-17A signaling axis and the development logic of dual-targeting strategies
2026-06-16IL-23 and IL-17A do not function in isolation but form a complete signaling axis from innate immunity to adaptive immunity, and from antigen presentation to tissue inflammation. The core components of this axis include: IL-23 activates the STAT3-RORγt transcriptional program via IL-23R, driving Th17 cell differentiation; Th17 cells secrete IL-17A and IL-17F; IL-17A activates the NF-κB and MAPK pathways in target tissues through IL-17RA/IL-17RC, inducing the expression of inflammatory genes.
View details
- Immunity/Inflamma
- IL-23/IL-17 axis
- Th17 regulatory network
- pathway crosstalk
- bispecific antibodies
- oral cyclic peptides
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