Technical Articles

osteoclast

重组小鼠m-csf蛋白：从集落刺激因子到 CSF1R 策略，它为什么成了免疫微环境的入口？

M-CSF in Drug Development: The CSF1R Gateway to the Immune Microenvironment

2026-10-14

CSF1R inhibitors opened macrophage-focused immunotherapy strategies. This article reviews CSF1R-directed approaches, tumor-associated macrophages and how recombinant mouse M-CSF supports translational research.

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Immunity/Inflamma
M-CSF
CSF1R
TAM
immune microenvironment
osteoclast
combination therapy
translational research
UA040128

Recombinant Mouse M-CSF: Driving Monocytes to Macrophages via CSF1R

2026-10-14

Mouse M-CSF (CSF1) binds CSF1R to drive monocyte survival, proliferation and differentiation into macrophages. This article explains the CSF1/CSF1R axis, BMDM generation and osteoclast biology.

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Immunity/Inflamma
M-CSF
CSF1
CSF1R
macrophage
monocyte
BMDM
osteoclast
TAM
UA040128

The role of IL-13 in exercise-induced skeletal muscle metabolic remodeling and its protein function study

2026-01-14

Exercise is an important way to prevent and improve metabolic syndrome and other diseases, and its beneficial effects independent of weight changes suggest the involvement of humoral factors in regulating metabolic adaptation during exercise.

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Metabolism
Osteoclast
Cytokine
Bone metabolic disease

Complete Guide to In Vitro Osteoclast Differentiation Experiment: From Principles to Practical Operation

2025-08-11

Bone is a dynamic tissue undergoing constant remodeling, with osteoclasts mediating resorption. Studying osteoclast differentiation is vital for understanding osteoporosis and bone metastasis. Due to challenges in primary cell expansion, in vitro induction remains the primary approach. This article outlines current strategies to guide future research.

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Signaling Pathway
osteoclast
BMMs

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