Technical Articles

CNTF is an IL-6 family neurotrophic cytokine acting through CNTFR/gp130/LIFR. This article covers its neuroprotective mechanisms, retinal ganglion cell evidence and activity determination with recombinant rat CNTF.

EPO is a four-helix-bundle glycoprotein hormone acting through the EPOR-JAK2/STAT5 axis. This article explains erythroid development, glycosylation-driven molecular-weight heterogeneity and non-hematopoietic activities in vascular and neural research

The neuroprotective effects of acupuncture are closely related to changes in various signaling pathways, and accumulating evidence suggests that endogenous biological mediators such as members of the neurotrophic protein family are involved.

EPO is a cytokine with complex and potent functions. The in-depth understanding of its mechanisms has not only driven innovations in anemia treatment but has also opened up new perspectives for treating neurological diseases and comprehending tumor biology. In the future, developing EPO drugs with higher tissue specificity will be a crucial direction for achieving precision medicine.