Technical Articles

mRNA

T7 High Yield RNA Synthesis Kit：转录产量由哪几个变量决定？

T7 In Vitro Transcription Yield: Which Variables Actually Decide It

2026-10-22

IVT yield is set by template quality, magnesium, NTP balance and reaction time. This article breaks down the variables that determine transcription output with a T7 RNA synthesis kit.

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Drug Research
T7 RNA polymerase
in vitro transcription
IVT yield
magnesium
NTP
template quality
mRNA
UA070079

5-Ethynyluridine: A Nucleoside Analog with Bioorthogonal Labeling Potential for mRNA Therapeutics

2026-01-15

To evaluate the impact of EU modification on mRNA function, the study synthesized YFP-encoding mRNAs with all uridines replaced by EU, Ψ, m1Ψ, or unmodified uridine (U).

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Stem Cells
Labeling EU
Nucleotide analog
mRNA

H-2Kb MHC四聚体揭示免疫途径对mRNA疫苗诱导肺驻留记忆T细胞分化的调控机制

H-2Kb MHC Tetramer Uncovers Immune Pathways Regulating mRNA Vaccine - Induced Lung - Resident Memory T Cell Differentiation

2025-05-12

mRNA vaccination has multiple immunological advantages. It can activate CD8 + T cells and CD4 + T cells and induce antibody production, forming an adaptive immune response network. It doesn't rely on viral - vector delivery systems, avoiding the potential limits of pre - existing vector immunity on booster vaccination. Also, the modular design of its industrial production process enables rapid large - scale preparation.

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Immunity/Inflamma
H-2Kb MHC tetramer
mRNA
T cells

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