Technical Articles

immunosuppression

TGF-β1 in Translation: Fibrosis, Tumor Microenvironment and Drug Strategies

2026-10-14

TGF-β1 sits at the center of fibrosis and immunosuppressive tumor microenvironment research. This article reviews ALK5 inhibitors, ligand traps and translational study design around TGF-β1.

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Signaling Pathway
TGF-β1 target
ALK5 inhibitor
ligand trap
tumor microenvironment
fibrosis
immunosuppression
UA040172

DcR3: From Driver of Tumor Immune Evasion to Inflammation Brake—Translational Prospects of a Two-Faced Target

2026-09-20

DcR3 promotes immune escape in the tumor microenvironment while acting as inhibitory feedback in chronic inflammation. This article reviews its bidirectional mechanisms, sources of expression regulation, variable-control essentials on both research f

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Immunity/Inflamma
DcR3
Tumor immune evasion
Chronic inflammation
Immunosuppression
Biomarker
UA019076

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