Technical Articles

This article systematically elaborates on the molecular characteristics and biological functions of hyaluronidase PH20 (SPAM1), focusing on its catalytic mechanism as a hyaluronic acid-specific hydrolase and its classic applications in enhancing tissue permeability and dissipating local edema. It particularly analyzes its clinical value and operational strategies in the emergency treatment of vascular embolism caused by hyaluronic acid injections.

Hyaluronidase is a key enzyme capable of degrading hyaluronic acid, hailed as the "wall-breaking expert" of the extracellular matrix. It plays a vital role in maintaining tissue permeability and promoting substance diffusion.

Hyaluronidase (HAase) is a type of glycosidase that specifically degrades hyaluronic acid (HA) and some glycosaminoglycans. It breaks down large substrates into small molecular fragments by cleaving β -1,4-glycosidic bonds. This characteristic makes it a key tool in the field of biomedicine