Technical Articles

hepatocellular carcinoma

MAT1A: From the Hepatic Methylation Engine to a Turning Point in Tumor Metabolism

2026-09-23

MAT1A is the methylation engine of the liver, yet hepatocellular carcinoma cells systematically switch it off and re-express MAT2A. This article dissects the MAT1A/MAT2A switch, its consequence chain and the contest between two intervention routes fr

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Metabolism
MAT1A
SAM
one-carbon metabolism
MAT2A
hepatocellular carcinoma
methylation
UA0800468

FGFR4: Why Hepatocellular Carcinoma Targeting Focuses on This Selective Receptor

2026-09-20

Among the four FGFR family members, FGFR4 alone resides in the liver and binds the KLB co-receptor. From an industry perspective, this article dissects the FGF19 axis, its association with hepatocellular carcinoma and the design logic of selective in

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Signaling Pathway
FGFR4
Hepatocellular carcinoma
FGF19
Selective inhibitor
Targeted therapy
UA011375

A Door That Needs Two Keys: How FGF19, FGFR4 and KLB Open the Gate

2026-09-20

The FGFR4 door opens only when both keys—FGF19 and KLB—are inserted at the same time. This article walks through the four-step assembly of the FGF19-FGFR4-KLB ternary complex and the full process of signal entry.

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Signaling Pathway
FGFR4
FGF19
Beta-Klotho
KLB
Ternary complex
Hepatocellular carcinoma
UA011375

Innovative Strategy for Engineering IL-21 Receptor to Enhance the Efficacy of TCR-T Cells Against Hepatocellular Carcinoma

2026-02-10

Hepatocellular carcinoma is the most common primary liver cancer and has limited response to conventional therapies. Adoptive T cell therapies (such as TCR-T therapy) have shown significant efficacy in hematologic malignancies.

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Cancer
IL-21R
TCR-T cell
Hepatocellular carcinoma

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