Technical Articles

glypican-3

GPC3: Molecular Mechanisms of Glypican-3 and the Landscape of HCC-Targeted Research

2026-09-29

GPC3 is a member of the GPI-anchored heparan sulfate proteoglycan family. This review covers its molecular structure, the Xq26.2 gene locus, its developmental-adult-tumor expression profile, and the panorama of liver cancer targeted research.

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Cancer
GPC3
glypican-3
hepatocellular carcinoma
HCC targeted therapy
heparan sulfate proteoglycan
UA016106

On in Embryos, Off in Adults, Out of Control in HCC: The Three Acts of GPC3

2026-09-29

GPC3 expression regulation plays out like a three-act drama: a debut in the embryo, a curtain call in adulthood, and a loss-of-control restart in hepatocellular carcinoma, with an overgrowth interlude in between. This article unpacks the logic of GPC

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Cancer
GPC3
glypican-3
hepatocellular carcinoma
hepatoblastoma
Simpson-Golabi-Behmel syndrome
UA016106

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