Technical Articles

fibrosis

TGF-β1 in Translation: Fibrosis, Tumor Microenvironment and Drug Strategies

2026-10-14

TGF-β1 sits at the center of fibrosis and immunosuppressive tumor microenvironment research. This article reviews ALK5 inhibitors, ligand traps and translational study design around TGF-β1.

View details

Signaling Pathway
TGF-β1 target
ALK5 inhibitor
ligand trap
tumor microenvironment
fibrosis
immunosuppression
UA040172

TGF-β1: Why the Latent Complex Guards Tissue Homeostasis

2026-10-14

TGF-β1 is secreted in a latent complex with LAP and LTBP. This article explains latency and activation, Smad2/3 and ALK5 signaling, and its roles in EMT and fibrosis.

View details

Signaling Pathway
TGF-β1
TGFB1
latent complex
LAP
LTBP
Smad2/3
ALK5
EMT
fibrosis
UA040172

PDGF-AA protein: The "Architect" of the Cellular World, Its Central Role in Repair, Fibrosis, and Tumors

2025-12-05

PDGF-AA is a unique homodimeric member of the platelet-derived growth factor family, renowned for its high-specificity affinity for the PDGFR-α receptor. As a potent mitogen and chemotactic factor, it plays a central role in embryonic development, tissue repair, and vascular homeostasis.

View details

Cancer
PDGF-AA
Platelet-Derived Growth Factor-AA
PDGFR-α
Fibrosis
Idiopathic Pulmonary Fibrosis (IPF)

Total 3

Go to