Technical Articles

A T-cell engager works like a wire: one end plugs into a tumor antigen, the other into CD3 epsilon-gamma. This article dissects immunological synapse formation, the ITAM phosphorylation cascade and the affinity safety valve across a four-step workflo

The same CD3 arm can be precision guidance or a cytokine storm. Along the design challenges of T-cell engagers, this article dissects why the CD3εγ heterodimer has become the standard starting tool for bispecific antibody development.