Technical Articles

ZAP-70
CD3 复合物与 T 细胞激活：从 ITAM 磷酸化到 TCE 设计基础
The CD3 Complex and T-Cell Activation: From ITAM Phosphorylation to TCE Design Foundations
发布时间 2026-09-20
Composed of εδ and εγ heterodimers plus ζζ, the CD3 complex is the transduction core of TCR signaling. This review covers its subunit composition, the ITAM phosphorylation hierarchy and the structural basis for T-cell engager design.
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  • Immunity/Inflamma
  • CD3
  • TCR complex
  • ITAM
  • ZAP-70
  • T-cell activation
  • CD3epsilon-gamma
  • UA016046
Total 1
  • 1
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