Technical Articles

UA019077

CHI3L1: Signaling Mechanisms and Disease Spectrum of Chitinase-Like Protein 1

2026-09-28

CHI3L1 (YKL-40) is a secreted glycoprotein of the glycoside hydrolase 18 family without enzymatic activity. This review covers its molecular features, receptor signaling network, attributes as a serum biomarker, and disease associations including ast

View details

Immunity/Inflamma
CHI3L1
YKL-40
chitinase-like protein 1
IL-13R alpha 2
Syndecan-1
liver fibrosis
UA019077

Orchestrating the Repair Site: Four Steps of CHI3L1 in Tissue Damage Response

2026-09-28

This article breaks down the molecular events of CHI3L1 in tissue repair and the tumor microenvironment in four steps: alarm signaling, matrix remodeling, immune polarization toward Th2 responses, and angiogenesis.

View details

Immunity/Inflamma
CHI3L1
YKL-40
tissue repair
inflammation
Th2 polarization
angiogenesis
UA019077

CHI3L1 Binding Assay Tools: QC Evidence and Platform Parameters of HEK293-Derived Recombinant Antigen

2026-09-28

The main challenges of CHI3L1 binding assays are glycosylation-dependent epitopes and endotoxin interference. This article reviews the QC evidence of HEK293-expressed recombinant CHI3L1, platform parameters for ELISA, SPR and cell-based assays, and t

View details

Immunity/Inflamma
CHI3L1 binding assay
YKL-40
recombinant protein
SPR
ELISA
endotoxin
UA019077

Total 3

Go to