Technical Articles

A tool-oriented guide to Plectin in vitro binding experiments: platform selection boundaries, buffer and centrifugation parameters, three common sources of false negatives and the logic behind three classes of controls, helping researchers build the

Loss of Plectin function follows one main thread—cytoskeletal cross-link failure leading to tissue mechanical fragility—manifesting as EBS-MD, peripheral neuropathy and mechanically driven tumor metastasis in different tissues. This article dissects

Plectin bridges actin microfilaments, microtubules and intermediate filaments through its N-terminal ABD, central coiled-coil rod and C-terminal plakin repeat domains. This article systematically reviews its structural boundaries, regulation, disease