Technical Articles

UA011375

FGFR4-Fc Fusion Protein Binding Assays: Ligands, Conditions and Interpretation

2026-09-20

A tool-oriented guide to FGFR4 binding experiments: the KLB co-receptor prerequisite, D2-D3 integrity quality control, SPR/ELISA parameter settings and troubleshooting paths for three types of data anomalies.

View details

Signaling Pathway
FGFR4 assay
Ligand binding
SPR
ELISA
KLB
SDS-PAGE
UA011375

FGFR4: Why Hepatocellular Carcinoma Targeting Focuses on This Selective Receptor

2026-09-20

Among the four FGFR family members, FGFR4 alone resides in the liver and binds the KLB co-receptor. From an industry perspective, this article dissects the FGF19 axis, its association with hepatocellular carcinoma and the design logic of selective in

View details

Signaling Pathway
FGFR4
Hepatocellular carcinoma
FGF19
Selective inhibitor
Targeted therapy
UA011375

A Door That Needs Two Keys: How FGF19, FGFR4 and KLB Open the Gate

2026-09-20

The FGFR4 door opens only when both keys—FGF19 and KLB—are inserted at the same time. This article walks through the four-step assembly of the FGF19-FGFR4-KLB ternary complex and the full process of signal entry.

View details

Signaling Pathway
FGFR4
FGF19
Beta-Klotho
KLB
Ternary complex
Hepatocellular carcinoma
UA011375

Total 3

Go to