Technical Articles

This article systematically elucidates the molecular mechanisms underlying the directional differentiation of naive CD4+ T cells into the Th1 subset driven by IL-12 and IFN-γ signaling, focusing on the molecular characteristics and polarization regulation of Th1 cells. It analyzes the pivotal roles of Th1 cells in anti-tumor immunity, anti-infection defense, and autoimmune diseases through the secretion of effector molecules such as IFN-γ, IL-2, and TNF-α.