Technical Articles

Targeted protein degradation

CRBN-DDB1 and Molecular Glues: From the Thalidomide Controversy to the New Paradigm of Targeted Degradation

2026-09-20

A once-withdrawn old drug revealed, sixty years later, an entirely new paradigm of targeted protein degradation. This article follows the timeline of how CRBN-DDB1 moved from the thalidomide mystery to center stage of molecular glue therapeutics.

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Drug Research
CRBN-DDB1
Molecular glue
Thalidomide
Lenalidomide
Targeted protein degradation
UA085062

The CRBN E3 ligase in targeted protein degradation technology and its application advantages

2026-01-05

Targeted Protein Degradation (TPD) technology is a hot field in recent drug development.

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Drug Research
VAV1/CRBN PROTAC Kit
Targeted protein degradation
E3 ligase

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