Technical Articles

TNFRSF17

Alexa Fluor 647荧光标记人BCMA蛋白：BCMA 这条 CAR-T 路线，为什么在多发性骨髓瘤里站住了？

BCMA as a CAR-T Route: Why It Has Held Its Ground in Multiple Myeloma

2026-10-20

This article reviews the BCMA CAR-T route in multiple myeloma: target biology, dual-epitope strategies and why release testing of BCMA-directed constructs depends on reliable target detection reagents.

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Cancer
BCMA CAR-T
multiple myeloma
TNFRSF17
dual epitope
target detection
release testing
UA011246

Alexa Fluor 647荧光标记人BCMA蛋白：CAR 表达检测为什么可以直接读荧光？

Alexa Fluor 647-Labeled BCMA: Why CAR Expression Detection Can Read Fluorescence Directly

2026-10-20

Directly labeled BCMA protein with Alexa Fluor 647 enables one-step flow cytometric detection of CAR expression. This article explains why the dye reads directly and how conjugation quality shapes the signal.

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Cancer
BCMA
TNFRSF17
CD269
Alexa Fluor 647
CAR expression detection
flow cytometry staining
direct labeling
UA011246

Understanding BCMA-Targeted Drugs: Why Can They "Precisely Target" Cancer Cells?

2025-07-25

B-cell maturation antigen (BCMA), also known as TNFRSF17 or CD269, is an important member of the tumor necrosis factor receptor superfamily (TNFRSF). In recent years, BCMA has garnered significant attention as a therapeutic target for multiple myeloma and other B-cell malignancies.

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Drug Research
BCMA
TNFRSF17
CD269

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