Technical Articles

This article focuses on the molecular characteristics and immune functions of Toll-like receptor 4 (TLR4), systematically elaborating its core role in activating dendritic cell maturation after chemotherapy drug-induced release of damage-associated molecular patterns from colorectal cancer cells, analyzing the driving mechanisms of TLR4-dependent DC activation on Th1 immune responses and in vivo antitumor effects, and exploring the clinical significance of TLR4 as an immune adjuvant pathway linking chemotherapy and antitumor immunity.