Technical Articles
TGF-β1
What Is TGF-β1: Latent Activation Mechanism and Activity Determination Guide
2026-10-14TGF-β1 acts through a latent-complex activation mechanism. This article explains latency, activation and Smad signaling, and how to determine activity of recombinant TGF-β1.
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- Signaling Pathway
- TGF-β1
- latent activation
- Smad2/3
- activity determination
- recombinant TGF-β1
- UA040172
TGF-β1: Why the Latent Complex Guards Tissue Homeostasis
2026-10-14TGF-β1 is secreted in a latent complex with LAP and LTBP. This article explains latency and activation, Smad2/3 and ALK5 signaling, and its roles in EMT and fibrosis.
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- Signaling Pathway
- TGF-β1
- TGFB1
- latent complex
- LAP
- LTBP
- Smad2/3
- ALK5
- EMT
- fibrosis
- UA040172
- 1
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