Technical Articles

TEAD2 is the transcriptional effector of the Hippo pathway. This article covers the YAP-TEAD axis, the YBD structural domain and binding validation of recombinant human TEAD2(YBD).

Recently, Michael N. Hall's team at the Biocenter of the University of Basel revealed a subversive discovery in the journal Molecular Cell - the transcription factor TEAD2 is actually the "behind-the-scenes director" of tumor metabolic reprogramming, driving the malignant progression of cancers such as hepatocellular carcinoma (HCC) by inhibiting the synthesis of acetyl-CoA.