Technical Articles

STAT5

IL-2: From T Cell Growth Factor to Immunoregulatory Hub - A Receptor Signaling Panorama

2026-09-22

A core member of the class I cytokine family, IL-2 activates the JAK1/JAK3-STAT5 pathway through its ternary receptor complex. This article reviews receptor composition, signaling hierarchy, affinity stratification, and immunoregulatory research tool

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Immunity/Inflamma
IL-2
IL-2 receptor
JAK1
JAK3
STAT5
Treg
biotinylated

One Receptor, Two Narratives: Why PRLR Has Returned to the Targeting Spotlight

2026-09-22

Once defined by lactation biology, the prolactin receptor PRLR has re-entered targeted research three decades later on the strength of high expression profiles in luminal breast cancer. This article unpacks the receptor's dual identity and translatio

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Metabolism
PRLR
prolactin receptor
breast cancer
STAT5
antagonist
target research

PRLR: Structural Isoforms, JAK2-STAT5 Signaling and the Research Landscape of the Prolactin Receptor

2026-09-22

A systematic review of the prolactin receptor (PRLR), a class I cytokine receptor family member that transmits prolactin signals via the JAK2-STAT5 pathway: receptor structure and isoforms, signaling hierarchy, physiological functions, and the toolki

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Metabolism
PRLR
prolactin receptor
JAK2
STAT5
breast cancer
recombinant protein

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