Technical Articles
SAM
The Ledger of a Single Methyl Group: How NNMT Rewrites Cellular Methylation Capacity
2026-09-20Picture the NNMT reaction as an accounting exercise: SAM is the wallet, SAH the IOU, and histone methylation is where the money is spent. This article walks through the bookkeeping and reconciliation of this methyl ledger in four steps.
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- Metabolism
- NNMT
- SAM
- SAH
- Histone methylation
- Epigenetics
- Metabolite quantification
- UA085036
NNMT Activity Assay Tools: Enzyme Reaction Systems, Platform Selection and Data Interpretation
2026-09-20A tool-oriented guide to NNMT activity assays: SAM stability management, interference control of SAH product inhibition, platform selection between luminescent coupling and LC-MS, and interpretation paths for three common data anomalies.
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- Metabolism
- NNMT assay
- Enzyme kinetics
- SAM
- SAH
- Luminescent coupling
- LC-MS
- UA085039
NNMT: An Epigenetic Switch on the Nicotinamide Metabolic Branch
2026-09-20NNMT catalyzes nicotinamide and SAM into 1-MNA and SAH, connecting the NAD+ salvage pathway with methylation metabolism. This review covers its catalytic mechanism, epigenetic effects, disease associations and in vitro research essentials.
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- Metabolism
- NNMT
- Nicotinamide N-methyltransferase
- 1-MNA
- SAM
- Epigenetics
- Cancer metabolism
- UA085039
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