Technical Articles

RTK

IGF1R/CD221: Structure, alpha2beta2 Assembly and the Tumor Research Landscape of a Receptor Tyrosine Kinase

2026-10-08

IGF1R/CD221 is a receptor tyrosine kinase of the insulin receptor family, assembled as an alpha2beta2 heterotetramer. This review covers its molecular architecture, IGF-1/IGF-2 ligand recognition, PI3K-AKT and RAS-RAF-MEK-ERK signaling, and key point

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Cancer
IGF1R
CD221
alpha2beta2
RTK
IGF-1
IGF-2
PI3K/AKT
RAS/RAF/MEK/ERK
UA016082

CD221/IGF1R Fc Chimeric Protein Binding Assays: Ligands, Conditions and Interpretation

2026-10-08

CD221/IGF1R Fc chimeric protein is a research tool for IGF-2 binding studies. This article covers Fc fusion design, HEK293-derived antigen QC, ELISA platform parameters and a three-class control troubleshooting path.

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Cancer
CD221
IGF1R
Fc chimeric protein
IGF-2 binding
ELISA
EC50
UA016082
alpha2beta2
RTK

The Hepatocyte Growth Factor Receptor (HGFR): A Pivotal Player in Physiology, Pathology, and Therapeutics

2025-07-09

The hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal epithelial transition factor (Met), is a receptor tyrosine kinase (RTK) that plays an important role in normal physiological processes and the occurrence and development of various diseases.

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Signaling Pathway
HGFR
HGF
RTK

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