Technical Articles

This article focuses on the molecular characteristics and biological functions of RSPO3 as a core member of the R-spondin family, systematically elucidating its dual mechanisms in regulating angiogenesis through both the canonical Wnt/β-catenin pathway and the non-canonical Gαi1/3-Akt-mTOR pathway.

RSPO3 is a key member of the R-spondin protein family. As a potent secreted protein, it plays a central role in embryonic development, tissue homeostasis, and disease pathogenesis by enhancing the Wnt/β-catenin signaling pathway.

RSPO3 (R-spondin 3) is a key member of the R-spondin protein family. As a multifunctional secreted glycoprotein, its most classic and widely recognized function is as a potent agonist of the classic Wnt/β - catenin signaling pathway. It effectively stabilizes and enhances Wnt signaling by binding to its receptor LRP6 and other receptors.