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RAS/RAF/MEK/ERK
IGF1R/CD221：受体酪氨酸激酶的结构、α₂β₂ 装配与肿瘤研究全景
IGF1R/CD221: Structure, alpha2beta2 Assembly and the Tumor Research Landscape of a Receptor Tyrosine Kinase
发布时间 2026-10-08
IGF1R/CD221 is a receptor tyrosine kinase of the insulin receptor family, assembled as an alpha2beta2 heterotetramer. This review covers its molecular architecture, IGF-1/IGF-2 ligand recognition, PI3K-AKT and RAS-RAF-MEK-ERK signaling, and key point
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  • Cancer
  • IGF1R
  • CD221
  • alpha2beta2
  • RTK
  • IGF-1
  • IGF-2
  • PI3K/AKT
  • RAS/RAF/MEK/ERK
  • UA016082
Total 1
  • 1
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