Technical Articles

This article focuses on the molecular characteristics and biological functions of R-Spondin 1 (RSPO1), systematically elaborating its domain composition as a core member of the R-spondin family. It analyzes the molecular mechanism by which RSPO1 enhances the Wnt/β-catenin signaling pathway through its furin-like domain binding to LGR4/5 receptors and neutralizing RNF43/ZNRF3-mediated ubiquitination degradation of Frizzled receptors.