Technical Articles

Mechanical forces travel from the extracellular matrix through integrin–focal adhesion complexes and the Plectin-bridged cytoskeletal network, ultimately shaping YAP/TAZ transcriptional responses. This article breaks down each segment of the chain an

Human Plectin is a family of variants generated by alternative splicing. From a tool perspective, this article maps the variant-to-localization relationships, sources of antibody epitope misjudgment and record-keeping standards, helping researchers k

Loss of Plectin function follows one main thread—cytoskeletal cross-link failure leading to tissue mechanical fragility—manifesting as EBS-MD, peripheral neuropathy and mechanically driven tumor metastasis in different tissues. This article dissects

Plectin bridges actin microfilaments, microtubules and intermediate filaments through its N-terminal ABD, central coiled-coil rod and C-terminal plakin repeat domains. This article systematically reviews its structural boundaries, regulation, disease