Technical Articles

This article systematically elucidates the molecular characteristics and biological functions of protein tyrosine kinase 7 (PTK7), focusing on its role as an inactive receptor tyrosine kinase in the co-receptor mechanisms of the Wnt and VEGF signaling pathways. It analyzes its low-level expression in normal tissues and its aberrant overexpression in various malignant tumors.

PTK7 (Protein Tyrosine Kinase 7) is a unique pseudokinase receptor that plays a key role in embryonic development, tissue polarity, and cell migration. Recent studies have found that PTK7 is abnormally expressed in various malignant tumors such as colon cancer and acute myeloid leukemia, making it an emerging biomarker for cancer diagnosis and targeted therapy.