Technical Articles

This article systematically elaborates on the advantages of targeted protein degradation strategies over traditional small-molecule inhibitors, focusing on the core technical challenges and latest advancements in PROTAC degrader development. It analyzes key design principles of PROTACs in terms of target selectivity, E3 ligase pairing, and ternary complex cooperativity, and explores emerging strategies such as tissue-specific E3 ligases, photo-controllable PROTACs, and antibody-PROTAC conjugates in enhancing tissue selectivity.