Technical Articles

PI3K/AKT

IGF1R/CD221: Structure, alpha2beta2 Assembly and the Tumor Research Landscape of a Receptor Tyrosine Kinase

2026-10-08

IGF1R/CD221 is a receptor tyrosine kinase of the insulin receptor family, assembled as an alpha2beta2 heterotetramer. This review covers its molecular architecture, IGF-1/IGF-2 ligand recognition, PI3K-AKT and RAS-RAF-MEK-ERK signaling, and key point

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Cancer
IGF1R
CD221
alpha2beta2
RTK
IGF-1
IGF-2
PI3K/AKT
RAS/RAF/MEK/ERK
UA016082

HER3 靶点的临床价值与 Patritumab Deruxtecan（U3-1402）的研发背景

The clinical value of HER3 target and the development background of Patritumab Deruxtecan (U3-1402)

2025-07-09

The human epidermal growth factor receptor (HER) family plays a key role in the occurrence and development of tumors, among which EGFR (HER1) and HER2 have been widely used as classic therapeutic targets in clinical practice, while HER3 (ERBB3), although started relatively late in research, has gradually gained attention in terms of its biological significance

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Cancer
Her3
PI3K/AKT
HER

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