Technical Articles

This article focuses on the molecular characteristics and biological functions of platelet-derived growth factor AA (PDGF-AA), systematically elaborating its structural features as an important ligand subtype of the PDGF family, its receptor-binding specificity, and the molecular mechanisms by which it activates signaling pathways such as PI3K/AKT and STAT3 through PDGFRα. It also analyzes its multifaceted roles in embryonic development, tissue repair, angiogenesis, and tumorigenesis.