Technical Articles

This article focuses on the molecular characteristics and biological functions of pregnancy-associated plasma protein-A2 (PAPP-A2), systematically elaborating its molecular mechanism as a secreted metalloproteinase of the pappalysin family that hydrolyzes IGFBP-3/5 to release free IGF-1, analyzing its core regulatory roles in placental development, postnatal linear growth, and bone metabolism, and exploring the clinical phenotypes of deficiency syndrome caused by PAPP-A2 gene mutations as well as the interventional value of recombinant IGF-1 replacement therapy.