Technical Articles

The same 29 kDa cytosolic enzyme is used by tumors to rewrite epigenetics and by adipose tissue to link with obesity. This article dissects the mechanism evidence and translational progress of NNMT along both disease lines.

Glucagon-like peptide-1 receptor (GLP-1R) agonists have revolutionized the treatment of type 2 diabetes and obesity over the past decade. However, the efficacy ceiling of single-target drugs and gastrointestinal tolerance issues have prompted researchers to explore more complex multi-target synergistic strategies.

With the continuous improvement of global living standards, the incidence of obesity and overweight continues to rise, posing a severe public health challenge. Currently, there remains a lack of effective treatments for overnutrition-induced obesity, which involves complex metabolic and immune regulatory mechanisms. Notably, obesity is often accompanied by a low-grade chronic inflammatory state, further triggering metabolic syndrome. However, the specific molecular mechanisms underlying this process remain unclear.