Technical Articles

Neurons and neuroglial cells are the basic units that constitute the structure and function of the nervous system.

PCSK9 is primarily synthesized and secreted by the liver as a serine protease, playing a crucial role in maintaining cholesterol homeostasis. PCSK9 elevates LDL-C levels by inhibiting circulating LDLR, competitively binding to LDLR on the surface of hepatocytes to form a PCSK9/LDLR complex. This complex is then transported into the cell via vesicles and degraded by lysosomes, leading to increased plasma LDL-C levels.

The neuroprotective effects of acupuncture are closely related to changes in various signaling pathways, and accumulating evidence suggests that endogenous biological mediators such as members of the neurotrophic protein family are involved.

Myelin basic protein is a protein specific to the central nervous system, localized on the cytoplasmic face of the myelin membrane, and tightly bound to myelin lipids, playing a key role in maintaining the structural stability and functional integrity of myelin.

Perioperative neurocognitive disorders (PND) refer to newly developed cognitive impairment or worsening of pre-existing cognitive function within 12 months before and after surgery, and are one of the most common complications in elderly surgical patients.

Transcriptional memory refers to the phenomenon where certain genes exhibit a faster and stronger response to a secondary stimulus after an initial exposure to signaling molecules.

In the field of neurodevelopmental disorders, there has been a long-standing clinical observation worth noting: some individuals with autism exhibit temporary improvement in behavioral symptoms during a fever.

Parkinson's disease is a common neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and abnormal accumulation of α-synuclein.

Transthyretin-related familial amyloid polyneuropathy (TTR-FAP) is an autosomal dominant inherited disorder caused by mutations in the transthyretin (TTR, also known as prealbumin) gene.

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive impairment, with pathogenesis involving multiple pathological processes such as amyloid-β (Aβ) deposition, abnormal phosphorylation of Tau protein, oxidative stress, and neuroinflammation.