Technical Articles

This article focuses on the molecular characteristics and metabolic regulatory functions of nicotinamide N-methyltransferase (NNMT), systematically elaborating its enzymatic mechanism as a cytoplasmic methyltransferase that catalyzes nicotinamide methylation using S-adenosylmethionine as the methyl donor, analyzing the association between upregulated NNMT expression in adipose tissue and liver with obesity and insulin resistance, and exploring the molecular pathways through which NNMT inhibition increases energy expenditure by elevating SAM and NAD⁺ levels, upregulating histone H3K4 methylation, and activating polyamine flux.