Technical Articles

From mouse to rhesus monkey, NNMT differs in sequence conservation, tissue expression profiles and model fit. This review covers the core dimensions of cross-species comparison and the logic of aligning tool proteins.

Picture the NNMT reaction as an accounting exercise: SAM is the wallet, SAH the IOU, and histone methylation is where the money is spent. This article walks through the bookkeeping and reconciliation of this methyl ledger in four steps.

A tool-oriented guide to non-human primate NNMT research: three layers of alignment—sequence identity verification, kinetic parallel testing and antibody cross-reactivity validation—plus QC interpretation of recombinant rhesus NNMT.

The same 29 kDa cytosolic enzyme is used by tumors to rewrite epigenetics and by adipose tissue to link with obesity. This article dissects the mechanism evidence and translational progress of NNMT along both disease lines.

NNMT catalyzes nicotinamide and SAM into 1-MNA and SAH, connecting the NAD+ salvage pathway with methylation metabolism. This review covers its catalytic mechanism, epigenetic effects, disease associations and in vitro research essentials.